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Symbol Name ID |
Mir155
microRNA 155 MGI:2676840 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Subacute progressive viral hepatitis |
Autoimmunity |
| Disease(s) Associated with MIR155 | ||
| hepatocellular carcinoma | ||
| type 1 diabetes mellitus |
| Mouse Phenotypes | immune system phenotype |
increased B cell proliferation |
intestinal inflammation |
thymus hyperplasia |
enlarged spleen |
increased spleen weight |
abnormal lymphopoiesis |
abnormal class switch recombination |
abnormal T-helper 17 cell differentiation |
decreased germinal center B cell number |
increased germinal center B cell number |
increased B cell number |
increased pre-B cell number |
decreased T-helper 17 cell number |
increased T-helper 2 cell number |
decreased effector memory T-helper cell number |
decreased regulatory T cell number |
decreased leukocyte cell number |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal T-helper 1 cell morphology |
intermingled spleen red and white pulp |
abnormal spleen B cell follicle morphology |
decreased spleen germinal center number |
decreased spleen germinal center size |
decreased spleen white pulp amount |
increased spleen white pulp amount |
abnormal B cell physiology |
abnormal germinal center B cell physiology |
decreased IgG1 level |
decreased IgM level |
abnormal T cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal immune system morphology |
abnormal gut-associated lymphoid tissue morphology |
abnormal Peyer's patch germinal center morphology |
enlarged lymph nodes |
abnormal immune system physiology |
abnormal dendritic cell physiology |
abnormal humoral immune response |
abnormal cytokine secretion |
decreased interferon-gamma secretion |
increased interleukin-10 secretion |
decreased interleukin-4 secretion |
decreased interleukin-6 secretion |
decreased tumor necrosis factor secretion |
decreased susceptibility to experimental autoimmune encephalomyelitis |
lung inflammation |
increased susceptibility to bacterial infection |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||
| Gt(ROSA)26Sortm1(Mirn155)Rsky/Gt(ROSA)26Sortm1(Mirn155)Rsky | |||||||||||||||||||||||||||||||||||||||||||||||||
| Mir155tm1.1Brd/Mir155tm1.1Brd | * | ||||||||||||||||||||||||||||||||||||||||||||||||
| Mir155tm1.1Rsky/Mir155tm1.1Rsky | |||||||||||||||||||||||||||||||||||||||||||||||||
| Mir155tm1Brd/Mir155tm1Brd | * | ||||||||||||||||||||||||||||||||||||||||||||||||
| Mir155tm1Rsky/Mir155tm1Rsky | |||||||||||||||||||||||||||||||||||||||||||||||||
| Tg(Igh-Mir155)8Cro/0 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Tg(Igh-Mir155)10Cro/0 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Gt(ROSA)26Sortm1(tTA,tetO-Mir155)Fjsl/Gt(ROSA)26Sor+ Tg(Nes-cre)1Wmz/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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